By Frederick W. Alt
Advances in Immunology, a customary and hugely revered book, offers present advancements in addition to entire stories in immunology. Articles handle the big variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored through the key scientists within the box, each one quantity presents up to date details and instructions for the future.
* Contributions from prime specialists * Informs and updates on the entire most recent advancements within the box
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Additional info for Advances in Immunology
48 Yoon Park et al. One of F-box proteins, Skp2, forms SCF complex and function in substrate recognition. , 2011). The report from Rodriguez et al. (2011) demonstrates that Skp2 deficiency results in the elevated protein levels of CDK inhibitors (CKIs) such as p27 and p130 and diminished cell cycle entry in LSK cells, leading to reduced short-term engraftment. In contrast, Wang et al. (2011) reveal that Skp2À/À LSK cells display promoted cell cycle entry due to the increased Cyclin D1 gene expression.
Moreover, BMI-1, which is a component of PRC1 and stimulates RING1B E3 activity, has been found to regulate self-renewal of HSCs. , 1995). , 2004; Rizo, Dontje, Vellenga, de Haan, & Schuringa, 2008). , 2003). Intracellular signal transduction via protein tyrosine kinases is implicated in a variety of cellular processes. The RING finger E3, c-Cbl, which targets activated receptor tyrosine kinases, negatively regulates HSC proliferation. Although c-CblÀ/À mice are viable and fertile, impaired HSC quiescence is found in those mice.
CYLD has been known to negatively regulate NF-κB activation in TCR signaling by removing K63-linked polyubiquitin chains from TAK1. , 2007). We recently reported that USP9X DUB plays a positive role for TCR-induced NF-κB activation via facilitating CBM complex formation (Park, Jin, & Liu, 2013). As there is still a lack of knowledge of DUBs that possibly play a crucial role in TCR-induced NF-κB signaling, future studies will be required to characterize and establish the role of DUBs. 4. Noncanonical NF-κB signaling: CD40 Engagement of a subset of TNFR family member, CD40 with its ligand CD40L on B cells activates noncanonical NF-κB signaling pathway in a ubiquitin–proteasome-dependent manner.